Cytogenetic studies can identify numerical and structural chromosomal abnormalities that are diagnostic and/or prognostic for certain types of leukemia, lymphoma, myelodysplasia and myeloproliferative disorders. Chromosome analysis is also used for staging lymphoma, monitoring treatment and predicting relapse. Leukemias and lymphomas can often be characterized by specific chromosome abnormalities. Chromosome analysis aids the physician in determining the precise diagnosis, prognosis and optimal treatment method.
CPT Codes:
88237(2), 88262(1), 88291(1)
Specimen Requirements:
Please Note: Use only unfixed material. For specimens not listed below please contact our Client Services Department to determine if they may be acceptable.
Peripheral Blood:
- Peripheral blood can yield diagnostic data in acute leukemias. The white blood count (WBC) is a rough guide to estimate circulating malignant cells. Generally, cells of interest are present in lower numbers in blood than in marrow, and collection volume must be adjusted accordingly.
- 5-10 ml (minimum 5 x 106 cell yield) in sodium heparin (green-top) tube. Cautionary Note: Lithium heparin also comes in green-top collection tubes. Do not collect in lithium heparin.
- Refrigerate specimen. Use cold pack for transport. Be sure cold pack is not in direct contact with specimen during transport.
- All specimens should be shipped to Genzyme on the day of collection. Delay in shipping may compromise cell viability and results.
Turnaround Time:
7-9 days
Client Services:
Oncology/Pathology
800-447-5816
Specimen Services/Pickup:
877-246-1226