Chronic lymphocytic leukemia (CLL)-MRD testing utilizes a 12-antibody flow cytometry panel in concert with a sequential gating strategy to isolate pure CLL B-cells from normal B-cells and regenerating cells. This process allows for the differentiation of 1 CLL cell in 10,000 normal B-cells and provides a quantitative measurement of the MRD status of patients with CLL who are undergoing therapy. Patients who achieve CLL-MRD-negative status have improved overall and progression-free survival. This test is not suitable for making primary diagnosis or monitoring unreated CLL patients with a high tumor load.
CPT Codes:
88184(1), 88185(11), 88188(1) (units of 88185 vary depending on the number of antibodies tested)
Specimen Requirements:
Please Note: There must be a minimum of 5 million cells in the specimen submitted to perform the test (10 million cells preferred).
- Peripheral Blood:
- 10-20 ml in sodium heparin (green-top) tube.
- Bone Marrow Aspirate:
- 2-3 ml in sodium heparin (green-top) tube.
Turnaround Time:
24-48 hours
Client Services:
Oncology/Pathology
800-447-5816
Specimen Services/Pickup:
877-246-1226