InSight® (Interphase FISH for Rapid Detection of Numerical Abnormalities of Chromosomes 13, 18, 21, X & Y)
InSight provides rapid preliminary detection of the most common chromosome aneuploidies in prenatal specimens. It is most useful in cases of unusual urgency (e.g., a pregnancy in which ultrasound abnormalities have been observed, or in cases of high-risk late gestational age). It is standard of care that patients having InSight also have chromosome analysis performed to confirm InSight findings and to identify other abnormalities undetectable by InSight.
InSight Analysis Only – Amniotic Fluid (Chromosome Analysis Performed Elsewhere)
CPT Codes:
88271(5), 88275(1), 88291(1)
Specimen Requirements:
Amniotic Fluid:
- 15 ml orange screw-top conical tube.
- 5 ml non-bloody fluid in screw-top polypropylene tube.
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Do not centrifuge for any reason.
Turnaround Time:
- 1-2 days from specimen receipt in laboratory for InSight results*
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*Specimens received on a Friday will not be reported out until the following Monday.
InSight and Chromosome Analysis – Amniotic Fluid
CPT Codes:
88235(2), 88267(1), 88271(5), 88275(1), 88291(2), 88280(1)
Specimen Requirements:
Amniotic Fluid:
- Two 15 ml orange-top tubes.
- Discard first 2 ml, then collect a minimum of 20 ml (15 ml for chromosome analysis and 5cc for Insight) in orange-top tubes.
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Do not centrifuge for any reason.
Turnaround Time:
- 1-2 days from specimen receipt in laboratory for InSight results*
- 5-10 days for chromosome analysis, average of 7 days
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*Specimens received on a Friday will not be reported out until the following Monday.
InSight and Chromosome Analysis – Chorionic Villi
CPT Codes:
88235(2), 88267(1), 88271(5), 88275(1), 88280(1), 88291(2)
88261(1) (With Direct Analysis of CVS Specimen)
Specimen Requirements:
Chorionic Villi:
- Sterile collection tube with Genzyme-provided transport medium.
- 30 mg in Genzyme-provided screw-top tube.
Turnaround Time:
- 1-2 days from specimen receipt in laboratory for InSight results*
- 5-8 days for chromosome analysis
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*Specimens received on a Friday will not be reported out until the following Monday.
InSight and Chromosome Analysis – PUBS or Newborn Blood
CPT Codes:
88230(2), 88262(1), 88271(5), 88275(1), 88291(2)
Specimen Requirements:
Blood:
- 1-2 ml whole blood in sodium heparin (green-top) tube.
Turnaround Time:
- 1-2 days from specimen receipt in laboratory for InSight results*
- 2-3 days for chromosome analysis
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*Specimens received on a Friday will not be reported out until the following Monday.
Client Services:
Reproductive/Genetics
800-848-4436
Specimen Services/Pickup:
877-246-1226