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Maternal Serum Alpha-Fetoprotein (MSAFP)

MSAFP is a single marker screening test performed on a maternal serum sample collected in the second trimester between 15 weeks / 0 days and 23 weeks / 6 days (15.0 - 23.9 weeks). The results provide a risk assessment for fetal open neural tube defects. It is appropriate to order this test following CVS or first trimester screening for fetal Down syndrome, as these analyses do not screen for open neural tube defects.

CPT Codes:

82105(1)


Specimen Requirements:
  1. Serum:
    • 2-3 ml (unhemolyzed) in AFP tube.
  2. Whole Blood:
    • Serum separator tube (SST) or red-top tube.
    • 7 ml in SST or 7 ml in red-top tube; allow to clot; centrifuge (15 minutes at 1,500 rpm) to prevent hemolysis.

Turnaround Time:

2-3 days


Client Services: Reproductive/Genetics   800-848-4436

Specimen Services/Pickup:  877-246-1226

Reproductive/Genetics Client Services

Tel: 800-848-4436