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SerumIntegratedScreen is a two-part test that screens for fetal Down syndrome, trisomy 18 and open neural tube defects. Between 10 weeks / 3 days and 13 weeks / 6 days (10.4-13.9 weeks, CRL=39-84mm), pregnancy-associated plasma protein (PAPP-A) is measured in a maternal blood sample. Then, patients are directed to come back between 15 weeks / 0 days and 21 weeks / 6 days (15.0-21.9 weeks) for a second blood draw. Alpha-fetoprotein (AFP), human chorionic gonadotropin (hCG), unconjugated estriol (uE3) and dimeric Inhibin-A are measured on the second sample. SerumIntegratedScreen combines these measurements to provide a single risk assessment in the second trimester.

CPT Codes:

82105(1), 84163(1), 84702(1), 86336(1), 82677(1)

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Specimen Requirements:

1. Serum:
   • Serum separator tube (SST).
   • 2 ml serum, in SST for both first and second trimester specimens.
2. Whole Blood:
   • Serum separator tube (SST) or red-top tube.
   • 7 ml in SST or 10 ml in red-top tube for both first and second trimester specimens; allow to clot, centrifuge (15 minutes at 1,500 rpm) to prevent hemolysis.
3. Dried Blood Spot:
   • Dried blood spots collected on Genzyme provided filter paper/test requisition.
   • Fill a minimum of three circles completely with blood. Please Note: If prenatal carrier screening for cystic fibrosis is ordered in conjunction with first trimester screening all six circles should be filled.
   • Please Note: Only the first trimester integrated sample (Part 1 of SerumIntegratedScreen) can be collected on dried blood spot filter paper. For the second trimester sample of SerumIntegratedScreen, please send whole blood or serum (see specimen requirements listed). Second trimester dried blood spot samples will be rejected and cancelled.
   • Please Note: Please do not send dried blood spot samples for second trimester samples of SerumIntegratedScreen.

Turnaround Time:

2-3 days (after second trimester specimen is received in laboratory)

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Client Services: Reproductive/Genetics   800-848-4436

Specimen Services/Pickup:  877-246-1226